To assess the relationship between miR-21 expression and MIR21 methylation status, we analyzed eight major cancer types, including breast cancer (BRCA), LUAD, KIRC, bladder urothelial carcinoma (BLCA), LIHC, lung squamous cell carcinoma (LUSC), kidney renal papillary cell carcinoma (KIRP), and PAAD in TCGA data. This evidence concerns the gene MIR21 and cancer.