COL4A1 and gastric cancer: Since HP infection often occurs in the early stage of GC, it is reasonable to assume that the abnormal expression of COL4A1 may not only affect the migration and invasion ability of GC cells, but it may also be involved in the induction of HP-related inflammatory stimuli and gastric epithelial carcinogenesis, which may lead to different histological origins of GC in early stage of different growth patterns.