The existence of circulating MYOM3 fragments was also investigated in four LGMD mouse models, that is, KO-calpain3 (model for LGMD R1 calpain3-related [LGMD2A]), KO-dysferlin (model for LGMD R2 dysferlin-related [LGMD2B]), KO-Sgcg (model for LGMD R5 γ-sarcoglycan-related [LGMD2C]), and KO-Sgca (model for LGMD R3 α-sarcoglycan-related [LGMD2D]), which showed interesting results.37 The gene discussed is MYOM3; the disease is limb-girdle muscular dystrophy.