Interestingly, a probe of bovine immunoglobulin epsilon heavy chain constant region mRNA (NCBI accession #: AY221098) displayed 3.9-fold increased signal intensity in carriers than in non-carriers (P = 0.02), indicating higher levels of IgE in carriers and indirectly supporting the increased production of LTB4 based on the role of LTB4 in allergy (102). Here, IGHE is linked to allergic disease.