The top five canonical pathways significantly over-represented by DEG were (1) integrin signaling, (2) Wnt/β-catenin signaling, (3) PI3K/AKT signaling, (4) colorectal cancer metastasis signaling, and (5) chronic myeloid leukemia signaling (Figure 1A). Here, AKT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.