IGHE and Allergy: Interestingly, a probe of bovine immunoglobulin epsilon heavy chain constant region mRNA (NCBI accession #: AY221098) displayed 3.9-fold increased signal intensity in carriers than in non-carriers (P = 0.02), indicating higher levels of IgE in carriers and indirectly supporting the increased production of LTB4 based on the role of LTB4 in allergy (102).