EFEMP1 and infection: Consistent with previous studies (Hulleman et al., 2011), luciferase activity in the cell culture media of RPE cells expressing mutant Fibulin-3 was 73.6 and 88.8% lower on the apical and basal sides, respectively, than that of cells expressing the WT form after 14 weeks of infection (n = 8, p < 0.01; Figure 6C).