CSF2RB and leukemia: They identified transforming hotspot mutation in myeloid cytokine receptor CSF2RB. Using a multiplex CRISPR/Cas9 screen in an in vivo murine TAM model, they found that loss of 18 from 22 tested recurrently mutated ML-DS genes led to leukemia phenotypically, genetically, and transcriptionally similar to ML-DS (21).