FLT3 and acute myeloid leukemia: GSEA showed that gene sets of AML with FLT3-ITD, HSC (hematopoietic stem cell)/LSC and CML (chronic myelocytic leukemia) quiescence were enriched in both SH3TC2-DT and SH3TC2 high-expression phenotype (Figures 8E, 9E).