Afterwards, through multivariate Cox proportional hazards regression analysis, we identified a 3-mRNA prognostic risk model to predict OS in AML cases as follows: risk score= (0.000612 × expression level of SH3TC2) + (0.000507 × expression level of ENPP2) + (0.000277 × expression level of TMEM273) (Table 2). This evidence concerns the gene SH3TC2 and acute myeloid leukemia.