Compared with FLT3-wildtype AML, 619 lncRNAs (113 upregulated and 506 downregulated) and 1,428 mRNAs (194 upregulated and 1,234 downregulated) were significantly differentially expressed in FLT3-mutated AML (FC> 2, FDR< 0.05) (Figures 2A,B). The gene discussed is FLT3; the disease is acute myeloid leukemia.