An indication of this was found in multiple myeloma patients since the fraction of CD14+CD16+ monocytes was significantly increased in patients with osteolytic bone disease compared with the controls.57 An alternative explanation for the correlation between the resorptive activity of in vitro-generated OCs and the age/menopausal status of the respective donors could be an age-related change in the expression of circulating miRNAs, known to function as RNA silencers and posttranscriptional regulators of gene expression.58,59. The gene discussed is CD14; the disease is plasma cell myeloma.