OVOL1 and allergic disease: We also identified that the rs479844 variant located near the AP5B1 and OVOL1 genes (effect allele A) was associated with a decrease in BMD and a decrease in the risk of atopic dermatitis, atopic march (atopic dermatitis in infancy and subsequent allergic rhinitis and asthma in later childhood)17 and allergic disease (asthma, hay fever or eczema).