We also identified that the rs479844 variant located near the AP5B1 and OVOL1 genes (effect allele A) was associated with a decrease in BMD and a decrease in the risk of atopic dermatitis, atopic march (atopic dermatitis in infancy and subsequent allergic rhinitis and asthma in later childhood)17 and allergic disease (asthma, hay fever or eczema). This evidence concerns the gene OVOL1 and asthma.