Mechanisms under the relationship between RDW and the 30-day mortality of SAE remain largely unknown, but several studies had revealed that the inflammatory response during sepsis may contribute to the adverse impact of RDW on the prognosis of SAE as RDW is positively associated with inflammatory markers, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) [36–39]. This evidence concerns the gene CRP and Sepsis.