Similarly, CRSwNP + AS patients had a significantly higher percentage of eosinophils (6.45%) and total IgE (143.00 kU/l) in peripheral blood compared to CRSwNP-alone patients (3.00% and 53.90 kU/l, respectively; Fig. 1a, b). The gene discussed is IGHE; the disease is chronic rhinosinusitis with nasal polyps.