In this respect, the well-known genes or biomarkers closely related to CRSwNP; for example CLC, POSTN, CCL18, IL13, TSLP and BPIFA1; were also identified as the top DE-mRNAs in both CRSwNP-alone and CRSwNP + AS groups. The gene discussed is BPIFA1; the disease is chronic rhinosinusitis with nasal polyps.