We found that the expression of cytokines IL5 and IL13, and receptors IL5RA and IL5RB, indicating augmented type 2 inflammation, was significantly enhanced in both CRSwNP-alone and CRSwNP + AS compared to control (Fig. 3d and Additional file 1: Table S4). The gene discussed is CSF2RB; the disease is chronic rhinosinusitis with nasal polyps.