Furthermore, in accordance with the findings of Tomassen and colleagues [15] that severe type 2 CRSwNP increased asthma prevalence, our study has also demonstrated that in addition to more frequent atopy, more local eosinophil infiltration, and higher level of tissue IgE, the chance of recurrence of CRSwNP was also increased in patients with CRSwNP + AS compared to patients with CRSwNP-alone. This evidence concerns the gene IGHE and asthma.