Importantly, the present study showed that some of the most significant DE-mRNAs; including ITLN1, KCNA3 and CCR10; which were up-regulated in nasal tissue of CRSwNP + AS compared to nasal tissue of CRSwNP-alone (Additional file 1: Figure S8), are also expressed in the bronchial tissue and contribute to the pathogenesis of asthma [42–44]. The gene discussed is KCNA3; the disease is chronic rhinosinusitis with nasal polyps.