CDKN2A and acral lentiginous melanoma: Others mutations observed in acral melanomas are PAK1, CDK4, CCND1, CDKN2A, PTEN, P16, MAP2K2, ARID2, MITF, TP53, RAC1, RB1, SPRED1 ALK, ROS1, RET and NTRK1 [19].