Though vinca alkaloid microtubule-destabilizing compounds have shown clinical efficacy against various hematological malignancies [25] and were included in combination chemotherapy of the VAPA study [26], they are not currently used in induction chemotherapy for AML due to their high toxicity against lymphoid cells and rapid degradation by myeloperoxidase in AML cells [27]. This evidence concerns the gene MPO and acute myeloid leukemia.