In begomoviral V2, two highly conserved protein domains have been identified to be essential for its activity as PTGS suppressor (Supplementary Figure S1): (i) a putative CK2/PKC (protein kinase CK2/protein kinase C) phosphorylation motif (Chowda-Reddy et al., 2008) and (ii) a CxC motif (Glick et al., 2008) that is also required for full infection (Hak et al., 2015). The gene discussed is PRRT2; the disease is infection.