Blocking EV with anti-MICA/B antibody reduced lysis down to a similar level to that of NOE targets, suggesting that this is indeed an important mechanism by which γδ T cells recognize and target T47D breast cancer cells (Figures S4M,N); however, the greater resistance of MDA-MB-231 compared to T47D cannot be solely attributed to NODAL, and we unfortunately did not measure matched MICA/B expression levels for shN and shC targets concurrent with our cytotoxicity assays. The gene discussed is MICA; the disease is breast carcinoma.