Additionally, RvD2 suppresses pro-inflammatory mediators by decreasing the plasma levels of IL-1β, IL-6, IL-17, IL-23, and TNF-α, as well as the levels of prostaglandin (PG)E2 and LTB4 in peritoneal exudates, as demonstrated using an animal sepsis model Interestingly, RvD2 decreases the plasma levels of the potent anti-inflammatory cytokine IL-10, which is of interest because of its detrimental impact on survival in sepsis (42). This evidence concerns the gene TNF and Sepsis.