CXCL8 and Hepatic fibrosis: Instead, the top canonical pathways for PBMCs after vaccination and prior to parasite challenge were colorectal cancer metastasis signaling (Z-score = −0.277), hepatic fibrosis signaling pathway (Z-score = −1), leukocyte extravasation signaling (Z-score = −0.378), and IL-8 signaling (Z-score = −0.707), all of which were predicted to be deactivated.