While the majority of the top canonical pathways were predicted to be deactivated, some pathways predicted to be activated include T cell exhaustion signaling pathway (Z-score = 1.155), PD-1, PD-L1 cancer immunotherapy pathway (Z-score = 1.387), calcium-induced T lymphocyte apoptosis (Z-score = 0.302), and interferon signaling (Z-score = 0.378) (Figure 7B bottom). Here, CD274 is linked to cancer.