The top pathways predicted to be deactivated were systemic lupus erythematosus in B cell signaling pathway (Z-score = −0.333), melanocyte development and pigmentation signaling (Z-score = −1), and phospholipase C signaling (Z-score = −0.447) mainly elicited by TNF family regulators, LAT, and PLCG2. This evidence concerns the gene PLCG2 and systemic lupus erythematosus.