While CVID can develop later in life and its causes are thought to be multifactorial (9), XLA is a congenital disease that is the result of a mutation in Bruton's tyrosine kinase, resulting in an early B cell defect and complete humoral immunodeficiency from birth, including IgG, IgA and IgM (12). The gene discussed is CD79A; the disease is common variable immunodeficiency.