IGHE and asthma: The major findings are briefly summarized as follows: (1) through EP4, PGE2 signaling decreases IgE production by inhibiting STAT6 activation and the transcription of downstream targets and attenuates the development of OVA-induced asthma; (2) PPARγ acts as an E3 ubiquitin ligase and induces phospho-STAT6 proteasome-dependent degradation in B cells.