CD8A and neoplasm: Firstly, in 1XX CAR treated mice, there was a higher accumulation of CAR-T cells at the tumor site, and both CD4+ and CD8+ CAR-T cell subsets showed a higher percentage of CD62L+CD45RA− central memory T cells (TCM) and a lower fraction of terminally differentiated CD62L−CD45RA+ effector cells (TEFF) (54).