We further found that the effects observed following myriocin treatment could be recapitulated by ablation of Sptlc2, specifically in the adipocyte, including the improvement in insulin sensitivity and glucose tolerance, resolution of hepatic steatosis, increased recruitment of M2 macrophages, recruitment of beige adipocytes in the adipose tissue, and improvement in mitochondrial respiration (35). This evidence concerns the gene INS and fatty liver disease.