The heart, lungs, brain, and blood vessels are among the organs in which the ACE2 product, Ang-(1-7) exerts actions that include cardioprotection, improvement of endothelial function, beneficial central actions (stroke, baroreflex, blood pressure, stress coping behaviors), anti-thrombogenic, anti-inflammatory, and pro-resolving effects (Figure 1; Santos et al., 2018). This evidence concerns the gene ACE2 and Stroke.