CYP2D6 and early-onset autosomal dominant Alzheimer disease: For the CYP2D6 rs1065852 polymorphism, Yuan Zhong et al. investigated the relationship of the CYP2D6*1/*1, CYP2D6*1/*10, and CYP2D6*10/*10 alleles in 106 Asian patients with mild to moderate Alzheimer's disease with DNP efficacy.