APOE and Mental deterioration: These mechanisms suggest that ABCA1 can reduce the production of Aβ by regulating cholesterol efflux and reducing the intracellular content of cholesterol, thereby improving cognitive decline, possibly in an APOE-dependent manner, while the cholesterol transporter ABCA1 neutralizes the Aβ aggregation capacity in an APOE-dependent manner (Lupton et al., 2014).