Despite their therapeutic effects, these drugs block TNF, resulting in several negative side effects, including low rate of disease remission, development of fatal adverse effects such as lupus-like symptoms and lymphoma, and production of antibodies against biological TNF inhibitor (Feldmann and Maini, 2015; Kalliolias and Ivashkiv, 2016). This evidence concerns the gene TNF and systemic lupus erythematosus.