To this end, the expression of the intermediate filament protein, vimentin (VIM), characteristically upregulated in cells during EMT,15 was correlated with the expression of all defined human DUBs,27 in normalised RNA-seq data of 517 lung adenocarcinoma (LUAD) and 1100 Breast invasive carcinoma (BRCA) tumour biopsies retrieved from The Cancer Genome Atlas (TCGA) Research Network: http://cancergenome.nih.gov/ (Fig. 1a). This evidence concerns the gene VIM and invasive breast carcinoma.