Pearson correlation coefficient (PCC) of the top significant hits (PCC ≥ 0.2) revealed a small number of cancer-type-specific DUBs, including USP4, previously shown to play a critical role in regulating EMT.10 One DUB, coincided in both LUAD and BRCA cohorts, displaying a significant positive correlation (PCC ≥ 0.2 and p < 0.05) with high VIM levels (Fig. 1b). The gene discussed is USP4; the disease is cancer.