Additionally, a spiking experiment with BT200 showed comparable concentration-effect curves on closure time and ristocetin induced aggregation in healthy volunteers and in a patient suffering from congenital thrombotic thrombocytopenic purpura, a condition where patients have ultra large VWF multimers and enhanced platelet aggregation24. The gene discussed is VWF; the disease is thrombotic thrombocytopenic purpura.