IL17A and tularemia: 5 In contrast, IL-17A can promote IFNγ production during kidney-ischaemic reperfusion injury,32 or Francisella tularensis infection.33 Importantly, the consequence of IL-17A-IFNγ cross-regulations in the context of type-2 inflammation has never been shown and here we reveal IFNγ downregulation as a new mechanism through which IL-17A establishes a protective type-2 response in the lung.