HINT1 and colonic neoplasm: Moreover, HINT1 deacetylation by SIRT1 promotes the association of HINT1 with β-catenin, thus inhibiting carcinogenesis through downregulating β-catenin oncogenic activity, which suggests that SIRT1 might serve as a tumor suppressor through deacetylation of HINT1 and β-catenin in colon cancer cells.