In conclusion, this study demonstrates that reversible acetylation of HINT1 at K21 and K30 by CBP and SIRT1 modulates the capacity of HINT1 to bind to β-catenin or MITF and in turn to control tumorigenic features in colon cancer and melanoma cells (Fig. 7h). The gene discussed is HINT1; the disease is malignant colon neoplasm.