HINT1 and malignant colon neoplasm: Because previous studies have shown that HINT1 acts as a tumor suppressor by inhibiting the transcriptional activities of several oncogenic transcription factors, such as β-catenin and MITF, in various cancer cell types8,11, this study evaluated whether reversible acetylation of HINT1 might affect the transcriptional activity of β-catenin in colon cancer cells.