More importantly, the most recent study showed that HINT1 was subjected to K21 acetylation and Y109 phosphorylation in activated mast cells16, and these modifications promote the formation of colonies of melanoma cells derived from human melanoma patients in soft agar, indicating a PTM-dependent regulatory mechanism that governs the binding capacity of HINT1 for MITF in melanoma cells16. Here, MITF is linked to melanoma.