In the KEGG pathway classification, the genes in modules are significantly enriched in focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, regulation of actin cytoskeleton, mineral absorption, small cell lung cancer, arrhythmogenic right ventricular cardiomyopathy (ARVC), proteoglycans in cancer, hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy. The gene discussed is PIK3CA; the disease is Arrhythmogenic right ventricular dysplasia.