Interestingly, serine type peptidase such as KLK2 (Table S1c, boxed in orange) are reported to activate plasminogen activator which plays important role in extracellular matrix (ECM) degradation67–69 suggesting that these lncRNAs may down-regulate serine-type peptidase so that tumor capsule can remain intact. This evidence concerns the gene KLK2 and neoplasm.