Of note, IgCaller identified three Ig rearrangements in two CLL cases [t(6;22) [IRF4-IGL] and t(1;22) [RCC1-IGL]; IGK insertion in LINC01475] that were not detected in previous WGS analyses (Supplementary Figs. 10 and 11)18. Here, IRF4 is linked to B-cell chronic lymphocytic leukemia.