By further confirmation using qRT-PCR, the transcription of the reprogramming factors (NANOG, OCT4, and SOX2) was enhanced by CENPW silencing in HCC cells (Figure S3), implying the possibility of reprogramming into cancer stem cells which characterized by inhibition of cell proliferation and metabolic changes [24,25]. Here, POU5F1 is linked to hepatocellular carcinoma.