Considering the FDA and EMA approval of baricitinib and tofacitinib for the treatment of adults affected by moderate to severe anti-TNF resistant RA and for the treatment of moderate to severe MTX-refractory RA, active PsA and moderate to severe anti-TNF-refractory ulcerative colitis respectively, other JAKi have been developed for RA, reaching, in two cases, the market. The gene discussed is TNF; the disease is rheumatoid arthritis.