CCN5 and type 2 diabetes mellitus: Closer evaluation of the T2D-associated APCs revealed high levels of differentially expressed genes between adipose tissue from obese and normal-weight individuals, including GPX3, which was upregulated in cells from normal-weight individuals that negatively correlated with insulin resistance, while WISP2 (CCN5) and AFT3 were upregulated in cells from T2D subjects and positively correlated with insulin resistance [21].