On the other hand, a diet containing these compounds improved spatial learning and memory deficits in the senescence-accelerated prone (SAMP8) mouse, an animal model of spontaneous overproduction of amyloid precursor protein (APP) and oxidative damage, suggesting that Bangle extract has neurotrophin-like activity and is beneficial for the prevention of age-related progression of cognitive impairment [19]. This evidence concerns the gene APP and Cognitive impairment.