CD81 and Alzheimer disease: The neurotoxicity of AD AEVs and NEVs was comparable to excitotoxicity by 10 μM glutamate, hence physiologically relevant [54], and was cell of origin-specific (astrocytic and neuronal) and independent of putative soluble co-precipitates, since no cell viability differences were observed in the neurons treated with nonspecific CD81+ and total EVs from the same AD participants (Figure 1c).