Taking advantage of the blood–brain barrier permeability to EVs from the brain to the periphery [28], we and others have isolated neuronal and astrocytic origin-enriched EVs (NEVs and AEVs, respectively) from plasma and human cells, through particle precipitation, followed by immunocapture with anti-GLAST and anti-L1CAM antibodies, respectively, and showed that they are carriers of AD pathogenic proteins [29,30,31]. This evidence concerns the gene L1CAM and Alzheimer disease.