CD81 and Alzheimer disease: For the AD participants, NEVs and AEVs had similar effects on MTT (AEVs vs. NEVs, p = 0.695), but AEVs decreased MTT compared to both CD81+ (p = 0.035) and total EVs (p = 0.029), and NEVs showed similar strong trends in pairwise comparisons (p = 0.087 and p = 0.067 respectively).