Next, to assess whether MAC assembly in situ on the plasma membrane underlies the neurotoxicity of AD AEVs and NEVs, we co-treated rat cortical neurons with CD59 and AEVs or NEVs from AD and control participants and found that CD59 abrogated the AD AEV- and NEV-mediated cell viability decrease on the MTT assay (Figure 5a). The gene discussed is CD59; the disease is Alzheimer disease.