The familial forms of PD are caused by autosomal dominant and recessive mutations in several genes such as α-Syn (SNCA), ubiquitin C-terminal hydrolase L1 (UCHL-1), phosphatase and tensin homolog-induced putative kinase 1 (PINK1), PARKIN (PRKN), protein deglycase (DJ-1) and leucine-rich repeat kinase 2 (LRRK2) [4]. The gene discussed is PRKN; the disease is Parkinson disease.