CYP3A5 and colon adenocarcinoma: In particular, G. biloba extract at 200 μg/mL increased by 9.5-fold human PXR activation [71] and the expression of PXR target genes, i.e., CYP3A4, CYP3A5 and ABCB1 (encoding P-gp) in human LS180 colon adenocarcinoma cells [71].