Concomitantly, by activating AMPK signaling, EGCG decreases the expression of endothelin-1 (ET-1), reduces the NLRP3-mediated inflammation and apoptosis [146] and regulates the antioxidant status in endothelial cells [147], thus improving endothelial function with synergistic mechanisms that contribute to lower blood pressure, reduce insulin resistance, and protect against myocardial ischemia–reperfusion injury in animal models of metabolic syndrome [34,148]. The gene discussed is EDN1; the disease is metabolic syndrome.