Moreover, via activation of AMPK [126] and PI3K/Akt pathway [127,128], EGCG is able to upregulate the expression and the membrane translocation of GLUT4 in muscle cells in vitro and in animal model of diet-induced obesity [41,129] and to improve glucose tolerance and fasting blood glucose in an genetic model of obesity and type 2 diabetes [99]. This evidence concerns the gene SLC2A4 and obesity due to melanocortin 4 receptor deficiency.