Yang et al. further elaborated the role of peroxidasin in cardiac hypertrophy and found that peroxidasin mediated AngII-induced cardiac hypertrophy via the Nox2/VPO1/HOCl/ERK1/2 redox signaling pathway where Ang II increased the hypertrophy-related gene (BNP/ANF) expression [71]. This evidence concerns the gene PXDN and cardiac hypertrophy.