In a non-alcoholic fatty liver disease (NAFLD) model with colon cancer splenic xenograft, a high-fat diet induced TAM M2 polarization and substantial IL-1β and vascular endothelial growth factor (VEGF) production in an NLR family CARD containing 4 (NLRC4)-dependent manner. Here, IL1B is linked to metabolic dysfunction-associated steatotic liver disease.