AHR and familial hypercholesterolemia: Considering the previously discussed activity of AhR in protecting from inflammatory damage and maintaining barrier integrity [131], it is not surprising that a diet rich in AhR ligands can prevent or halt tumorigenesis [293] and that restoring AhR signaling rescues metabolic syndrome [294], a disorder characterized by a cluster of diseases, including visceral obesity, low high-density lipoprotein, hypertension, hyperglycemia, and hypercholesterolemia [295].