A crucial results underlying such condition in a highly hypoxia tumor microenvironment (TME) is metabolic reprogramming of tumor cells [18], such as, glycolysis is an adaptation to this low oxygen pressure microenvironment for activation by hypoxia-inducible factor 1 subunit alpha (HIF1A) which can stimulate glycolytic by transactivation genes involved in SLC2A1 and ALDOA [19]. The gene discussed is HIF1A; the disease is neoplasm.