NLRP3 and Parkinson disease: Furthermore, the hepatic inhibition of NLRP3 was also shown to attenuate dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD, outlining the role of systemic activation of NLRP3 in PD.