Modulation of NLRP3 activation with miR-7 [100], the peroxisome proliferator-activated receptor (PPAR) agonist GW501516 [102], or caspase-1 inhibition [103] have all been reported to alleviate dopaminergic degeneration in PD mouse models, providing possible novel therapeutic targets. Here, CASP1 is linked to Parkinson disease.