Eleven proteins were exclusively found in plasma-EVs from GBM patients, i.e., AIDA, ARHGEF10, BNIP3L, FYB1, KMT2D, MAP7, MAST4, PDE8A, POLR2D, RENBP and SLC25A17 (Figure 5A). The gene discussed is PDE8A; the disease is glioblastoma.