Four proteins were identified with significantly lower levels in IDH-wt GBM relative to IDH-mut AST, i.e., TIPIN (−50-fold), NUF2 (−16.7-fold), SMARCE1 (−10-fold) and PIEZO1 (−2.4-fold; Table S10), and the utility of these discriminating protein markers should be further investigated. This evidence concerns the gene PIEZO1 and glioblastoma.