Twelve of these neurosurgical aspirate EV proteins also showed significance in GBM plasma-EVs, including ANXA2, UQCRC2, COX5A, NDUFS4, IARS, TMEM65, CCT7, PSMC3, CCT2, GABBR1, SCD5 and TOMM40 (Figure 6A). This evidence concerns the gene ANXA2 and glioblastoma.