Familial hypercholesterolemia (FH) and elevated Lp(a) are a double heritable risk [8], i.e., carriers of a receptor-negative mutation in the low-density lipoprotein receptor (LDLR) gene with high Lp(a) (> 50 mg/dL) show a higher cardiovascular disease (CVD) risk compared to patients with the same mutation and Lp(a) levels < 50 mg/dL [9]. This evidence concerns the gene LDLR and cardiovascular disorder.