HOXD8 and prostate carcinoma: Similarly, HOXD3 hypermethylation is part of a panel that includes HOXD8 methylation [94], which makes it possible to test the clinical significance of prostate cancer using urine samples [29], and is also considered to be among the prognostic indicators of late recurrence or of the need for hormone therapy after surgery in prostate cancer biopsies [118].