HOXA5 and acute myeloid leukemia: In addition, the hypermethylation of HOXA5, together with five other genes (ABCA3, COX7A1, SLIT3, SOX17, SPARCL1), has been linked to lung adenocarcinoma development [107], while HOXA4 and HOXA5 present altered methylation profiles in a significant number of patients with acute myeloid leukemia [108].