TNF and psoriasis: Furthermore, Kathuria et al. supported the conclusion that psoriasis and PsA were associated with osteopenia, OP, and pathologic fractures and that the increased concentrations of TNF-α and IL-6 were involved in the potential association between psoriatic disease and reduced BMD, proposing that systemic treatment options reducing inflammation, such as methotrexate or biologics, may actually reduce the risk for OP and fractures [46].