PPARGC1A and Parkinson disease: The AMP-activated kinase (AMPK)/peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α) signaling pathway is one pathway that regulates mitochondrial biogenesis, and is also associated with the control of oxidative stress, which may increase the risk of onset of PD [156,157].