CD40LG and dengue disease: Primary infection of patients can be caused by any one of the four serotypes of DENV (DENV1, 2, 3, and 4) and secondary infection of these patients with a heterologous serotype increases the risk of progressing into severe dengue due to antibody-dependent enhancement [22,23] Furthermore, compared with NS1 or anti-DENV IgM, DENV particles are the first to be detected in dengue patient serum post symptom onset [21] The serotype-specific detection of DENV will be more time-effective for DENV diagnosis and more meaningful for clinical treatments.